The owners of The Grange were Thomas Drewe (1584-1651) and his wife, Elizabeth Moore Drewe (1585-1635). They had eleven children, of whom nine lived to at least early adulthood. They would have had numerous servants, who would have done the cleaning, cooking, repairs, sewing, and other practical tasks, as well as being governesses and nurses to the children, waiting on the family at the table, and assisting them in dressing and grooming themselves.

Drewe was prominent locally, serving in 1634 as the High Sheriff of Devon (the sheriff was the county tax collector, which was a very lucrative position). The lands surrounding the house, which would have been used for farming under lease to tenant farmers, consisted of 3,668 acres, growing wheat and other food crops, and raising livestock. The Grange was in a very rural setting of villages and fields. The river Tale, a tributary of the Otter River, flows through the property on the way to the English Channel, and the house overlooks a ridge called the Blackdown Hills.